01
Mar
Human studies have provided evidence suggestive of reproductive toxicity some evidence of an association between exposure to ethylene oxide and genetic damage to somatic cells and limited evidence of carcinogenicity. Although the main metabolite in rat urine is 2-methoxyethoxyacetic acid numerous studies indicate that 2-methoxyacetic acid is the metabolite responsible for the toxicity of diglyme for the male reproductive organs.
In vivo urea is formed in the liver via the urea cycle from ammonia and is the final end product of protein metabolism.
Reproductive toxicity protein adduct. Human studies have provided evidence suggestive of reproductive toxicity some evidence of an association between exposure to ethylene oxide and genetic damage to somatic cells and limited evidence of carcinogenicity. Acute lethality studies in experimental animals showed that mice are the most sensitive species 4-h LC 50 concentration with 50 lethality 660 to 835 ppm followed by the. Scatter plots of A percentage GSH adduct formation and B estimated total daily covalent adduct burden in drug-induced toxicity DIT Δ and non-drug-induced toxicity Non-DIT O groups of chemicals.
60 Horizontal lines are drawn at a A 02 adduct level and B 1 mg body level. Urea is a nitrogenous compound containing a carbonyl group attached to two amine groups with osmotic diuretic activity. In vivo urea is formed in the liver via the urea cycle from ammonia and is the final end product of protein metabolism.
Administration of urea elevates blood plasma osmolality resulting in enhanced flow of water from tissues including the brain cerebrospinal fluid and eye. Although the main metabolite in rat urine is 2-methoxyethoxyacetic acid numerous studies indicate that 2-methoxyacetic acid is the metabolite responsible for the toxicity of diglyme for the male reproductive organs. 2-methoxyacetic acid was transferred to the fetus and found as the sole metabolite in the fetus no parent compound was detected in the fetus either after dosing diglyme to mice.
Benzoapyrene is a polycyclic aromatic hydrocarbon and the result of incomplete combustion of organic matter at temperatures between 300 C 572 F and 600 C 1112 FThe ubiquitous compound can be found in coal tar tobacco smoke and many foods especially grilled meats. The substance with the formula C 20 H 12 is one of the benzopyrenes formed by a benzene ring fused to pyrene. Purchase Encyclopedia of Toxicology - 3rd Edition.
Print Book E-Book.